TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells

The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool, being RAI therapy the systemic treatment of choice for metasta...

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Bibliographic Details
Published in:PLoS One
Main Authors: Faria, Márcia, Domingues, Rita, Paixão, Francisca, Bugalho, Maria João, Matos, Paulo, Silva, Ana Luísa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015378/
https://ncbi.nlm.nih.gov/pubmed/32049985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228794
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