A Fixed-Depth Microneedle Enhances Reproducibility and Safety for Corneal Gene Therapy

Drug delivery directly to the corneal stroma currently relies on microscopic injections that demonstrate low reproducibility and clinician-dependent variability. With use of biological drugs such as adeno-associated viral (AAV) vectors, precise and consistent drug deposition is critical to reduce co...

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Bibliographic Details
Published in:Cornea
Main Authors: Gilger, Brian C., Crabtree, Elizabeth, Song, Liujiang, Llanga, Telmo, Cullen, Megan, Blanchard, Allison, Salmon, Jacklyn, Patel, Samirkumar, Zarnitsyn, Vladimir, Hirsch, Matthew
Format: Artigo
Language:Inglês
Published: Cornea 2020
Subjects:
Basic Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015188/
https://ncbi.nlm.nih.gov/pubmed/31724981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ICO.0000000000002182
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