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Ocular Tolerability and Immune Response to Corneal Intrastromal AAV-IDUA Gene Therapy in New Zealand White Rabbits

The chronic ocular toxicity, tolerability, and inflammation following corneal intrastromal injection of saline or escalating doses of an adeno-associated virus (AAV) containing a codon-optimized α-l-iduronidase (AAV-opt-IDUA) expression cassette were evaluated in New Zealand White rabbits. Corneal o...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Song, Liujiang, Bower, Jacquelyn J., Llanga, Telmo, Salmon, Jacklyn H., Hirsch, Matthew L., Gilger, Brian C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284066/
https://ncbi.nlm.nih.gov/pubmed/32542182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.014
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