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Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition
Glioblastomas are among the most lethal cancers, with a 5 year survival rate below 25%. Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA-N-glycosylase (APNG) and methylguanine-DNA-methyltransferase (MGMT) efficiently mediate the repair of DNA damage caus...
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| Publicado no: | J R Soc Interface |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7014791/ https://ncbi.nlm.nih.gov/pubmed/31964274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2019.0722 |
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