Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer’s disease-like pathology

Autosomal dominant Alzheimer disease (AD) is caused by rare mutations in one of three specific genes. This is in contrast to idiopathic, late-onset AD (LOAD), which has a more polygenetic risk profile and represents more than 95% of cases. Previously, we have demonstrated that increased expression o...

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Publicado no:Brain Res
Main Authors: Sarkar, S., Engler-Chiurazzi, E.B., Cavendis, J.Z., Povroznik, J.M., Russell, A.E., Quintana, D.D., Mathers, P.H., Simpkins, J.W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7014559/
https://ncbi.nlm.nih.gov/pubmed/31295467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2019.146327
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