Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel β-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation

Anti-tumor necrosis factor alpha (TNF-α) antibodies are effective in patients with inflammatory bowel disease (IBD). However, the effect is not optimal because a sufficient concentration of antibodies cannot be maintained at the site of inflammation. Thus, a macromolecular complex was developed with...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Sakisaka, Hideto, Takedatsu, Hidetoshi, Mitsuyama, Keiichi, Mochizuki, Shinichi, Sakurai, Kazuo, Sakisaka, Shotaro, Hirai, Fumihito
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7014273/
https://ncbi.nlm.nih.gov/pubmed/31968666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020683
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