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Allosteric Binding Sites On Nuclear Receptors: Focus On Drug Efficacy and Selectivity
Nuclear receptors (NRs) are highly relevant drug targets in major indications such as oncologic, metabolic, reproductive, and immunologic diseases. However, currently, marketed drugs designed towards the orthosteric binding site of NRs often suffer from resistance mechanisms and poor selectivity. Th...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7014104/ https://ncbi.nlm.nih.gov/pubmed/31947677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020534 |
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