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Synthesis of Spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity
Bergamottin (BM, 1), a component of grapefruit juice, acts as an inhibitor of some isoforms of the cytochrome P450 (CYP) enzyme, particularly CYP3A4. Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized; chemically characterized, evaluated as a potentia...
Wedi'i Gadw mewn:
Cyhoeddwyd yn: | Int J Mol Sci |
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Prif Awduron: | , , , , , , , , , , |
Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
MDPI
2020
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7013880/ https://ncbi.nlm.nih.gov/pubmed/31941150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020508 |
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