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Synthesis of Spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity

Bergamottin (BM, 1), a component of grapefruit juice, acts as an inhibitor of some isoforms of the cytochrome P450 (CYP) enzyme, particularly CYP3A4. Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized; chemically characterized, evaluated as a potentia...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Mol Sci
Prif Awduron: Zsidó, Balázs Zoltán, Balog, Mária, Erős, Nikolett, Poór, Miklós, Mohos, Violetta, Fliszár-Nyúl, Eszter, Hetényi, Csaba, Nagane, Masaki, Hideg, Kálmán, Kálai, Tamás, Bognár, Balázs
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013880/
https://ncbi.nlm.nih.gov/pubmed/31941150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020508
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