Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis

Matrilins (MATN1, MATN2, MATN3 and MATN4) are adaptor proteins of the cartilage extracellular matrix (ECM), which bridge the collagen II and proteoglycan networks. In humans, dominant-negative mutations in MATN3 lead to various forms of mild chondrodysplasias. However, single or double matrilin knoc...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Li, Ping, Fleischhauer, Lutz, Nicolae, Claudia, Prein, Carina, Farkas, Zsuzsanna, Saller, Maximilian Michael, Prall, Wolf Christian, Wagener, Raimund, Heilig, Juliane, Niehoff, Anja, Clausen-Schaumann, Hauke, Alberton, Paolo, Aszodi, Attila
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013758/
https://ncbi.nlm.nih.gov/pubmed/31963938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020666
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