The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients

Epidermal keratinocytes represent a rich source of C-C motif chemokine 20 (CCL20) and recruit CCR6(+) interleukin (IL)-17A–producing T cells that are known to be pathogenic for psoriasis. A previous study revealed that scratch injury on keratinocytes upregulates CCL20 production, which is implicated...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Furue, Kazuhisa, Ito, Takamichi, Tanaka, Yuka, Hashimoto-Hachiya, Akiko, Takemura, Masaki, Murata, Maho, Kido-Nakahara, Makiko, Tsuji, Gaku, Nakahara, Takeshi, Furue, Masutaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013594/
https://ncbi.nlm.nih.gov/pubmed/31936670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020434
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