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Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects

Epigenome editing is a promising technology, potentially allowing the stable reprogramming of gene expression profiles without alteration of the DNA sequence. Targeted DNA methylation has been successfully documented by many groups for silencing selected genes, but recent publications have raised co...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Hofacker, Daniel, Broche, Julian, Laistner, Laura, Adam, Sabrina, Bashtrykov, Pavel, Jeltsch, Albert
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013458/
https://ncbi.nlm.nih.gov/pubmed/31941101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020502
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