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Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects

Epigenome editing is a promising technology, potentially allowing the stable reprogramming of gene expression profiles without alteration of the DNA sequence. Targeted DNA methylation has been successfully documented by many groups for silencing selected genes, but recent publications have raised co...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Hofacker, Daniel, Broche, Julian, Laistner, Laura, Adam, Sabrina, Bashtrykov, Pavel, Jeltsch, Albert
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013458/
https://ncbi.nlm.nih.gov/pubmed/31941101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21020502
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