A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia

Targeted RNA sequencing detected a cryptic G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia and normal FISH studies. Consistent with the patient’s response to imatinib, we demonstrate this rearrangement is oncogenic and sensitive to TKI in cell culture.

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Jan, Max, Grinshpun, Daniel E., Villalba, Julian A., Dal Cin, Paola, Sykes, David B., Iafrate, A. John, Ebert, Benjamin L., Hobbs, Gabriela S., Nardi, Valentina
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Exceptional Case Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013269/
https://ncbi.nlm.nih.gov/pubmed/31999327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001182
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