Tisagenlecleucel cellular kinetics, dose, and immunogenicity in relation to clinical factors in relapsed/refractory DLBCL

The anti-CD19 chimeric antigen receptor (CAR)–T cell therapy tisagenlecleucel was evaluated in the global, phase 2 JULIET study in adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). We correlated tisagenlecleucel cellular kinetics with clinical/product parameters in 111 p...

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Pubblicato in:Blood Adv
Autori principali: Awasthi, Rakesh, Pacaud, Lida, Waldron, Edward, Tam, Constantine S., Jäger, Ulrich, Borchmann, Peter, Jaglowski, Samantha, Foley, Stephen Ronan, van Besien, Koen, Wagner-Johnston, Nina D., Kersten, Marie José, Schuster, Stephen J., Salles, Gilles, Maziarz, Richard T., Anak, Özlem, del Corral, Christopher, Chu, Jufen, Gershgorin, Irina, Pruteanu-Malinici, Iulian, Chakraborty, Abhijit, Mueller, Karen Thudium, Waller, Edmund K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Clinical Trials and Observations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013261/
https://ncbi.nlm.nih.gov/pubmed/32045475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000525
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