Post-treatment with Posiphen Reduces Endoplasmic Reticulum Stress and Neurodegeneration in Stroke Brain

Acetylcholinesterase (AChE) inhibitors have protective and anti-inflammatory actions against brain injury, mediated by nicotinic α7 cholinergic receptor activation. The use of AChE inhibitors in patients is limited by systemic cholinergic side effects. Posiphen, a stereoisomer of the AChE inhibitor...

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Published in:iScience
Main Authors: Yu, Seong-Jin, Wu, Kuo-Jen, Bae, Eunkyung, Wang, Yu –Syuan, Chiang, Chia-Wen, Kuo, Li-Wei, Harvey, Brandon K., Greig, Nigel H., Wang, Yun
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013187/
https://ncbi.nlm.nih.gov/pubmed/32058974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100866
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