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Non-secretory renin reduces oxidative stress and increases cardiomyoblast survival during glucose and oxygen deprivation

Although the renin-angiotensin system usually promotes oxidative stress and cell death, renin transcripts have been discovered, whose transcription product may be cardioprotective. These transcripts encode a non-secretory renin isoform that is localized in the cytosol and within mitochondria. Here w...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Wanka, Heike, Lutze, Philipp, Staar, Doreen, Albers, Alexander, Bäumgen, Inga, Grunow, Bianka, Peters, Jörg
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012910/
https://ncbi.nlm.nih.gov/pubmed/32047214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59216-8
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