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High pressure inhibits signaling protein binding to the flagellar motor and bacterial chemotaxis through enhanced hydration

High pressure below 100 MPa interferes inter-molecular interactions without causing pressure denaturation of proteins. In Escherichia coli, the binding of the chemotaxis signaling protein CheY to the flagellar motor protein FliM induces reversal of the motor rotation. Using molecular dynamics (MD) s...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Hata, Hiroaki, Nishihara, Yasutaka, Nishiyama, Masayoshi, Sowa, Yoshiyuki, Kawagishi, Ikuro, Kitao, Akio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012829/
https://ncbi.nlm.nih.gov/pubmed/32047226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59172-3
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