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High pressure inhibits signaling protein binding to the flagellar motor and bacterial chemotaxis through enhanced hydration

High pressure below 100 MPa interferes inter-molecular interactions without causing pressure denaturation of proteins. In Escherichia coli, the binding of the chemotaxis signaling protein CheY to the flagellar motor protein FliM induces reversal of the motor rotation. Using molecular dynamics (MD) s...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Hata, Hiroaki, Nishihara, Yasutaka, Nishiyama, Masayoshi, Sowa, Yoshiyuki, Kawagishi, Ikuro, Kitao, Akio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012829/
https://ncbi.nlm.nih.gov/pubmed/32047226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59172-3
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