mTOR Inhibitor Therapy Diminishes Circulating CD8(+) CD28(−) Effector Memory T Cells and Improves Allograft Inflammation in Belatacept-Refractory Renal Allograft Rejection

BACKGROUND: Renal allograft rejection is more frequent under belatacept-based, compared to tacrolimus-based, immunosuppression. We studied kidney transplant recipients experiencing rejection under belatacept-based early corticosteroid withdrawal following T cell depleting induction in a recent rando...

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Détails bibliographiques
Publié dans:Transplantation
Auteurs principaux: Castro-Rojas, Cyd M., Godarova, Alzbeta, Shi, Tiffany, Hummel, Sarah A., Shields, Adele, Tremblay, Simon, Alloway, Rita R., Jordan, Michael B., Woodle, E. Steve, Hildeman, David A.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012662/
https://ncbi.nlm.nih.gov/pubmed/31415033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000002917
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