Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model

Aberrant glycosylation resulting from altered expression of sialyltransferases, such as ST3 β-galactoside α2-3-sialyltransferase 6, plays an important role in disease progression in multiple myeloma (MM). Hypersialylation can lead to increased immune evasion, drug resistance, tumor invasiveness, and...

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Publicado no:Haematologica
Main Authors: Natoni, Alessandro, Farrell, Mariah L., Harris, Sophie, Falank, Carolyne, Kirkham-McCarthy, Lucy, Macauley, Matthew S., Reagan, Michaela R., O’Dwyer, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012485/
https://ncbi.nlm.nih.gov/pubmed/31101754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.212266
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