Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias. RAF kinase inhibitor protein (RKIP) is a negative regulator of RAS-signaling. As RKIP loss ha...

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Publicado no:Haematologica
Main Authors: Caraffini, Veronica, Geiger, Olivia, Rosenberger, Angelika, Hatzl, Stefan, Perfler, Bianca, Berg, Johannes L., Lim, Clarice, Strobl, Herbert, Kashofer, Karl, Schauer, Silvia, Beham-Schmid, Christine, Hoefler, Gerald, Geissler, Klaus, Quehenberger, Franz, Kolch, Walter, Athineos, Dimitris, Blyth, Karen, Wölfler, Albert, Sill, Heinz, Zebisch, Armin
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012480/
https://ncbi.nlm.nih.gov/pubmed/31097632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.209650
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