Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias. RAF kinase inhibitor protein (RKIP) is a negative regulator of RAS-signaling. As RKIP loss ha...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Haematologica
Main Authors: Caraffini, Veronica, Geiger, Olivia, Rosenberger, Angelika, Hatzl, Stefan, Perfler, Bianca, Berg, Johannes L., Lim, Clarice, Strobl, Herbert, Kashofer, Karl, Schauer, Silvia, Beham-Schmid, Christine, Hoefler, Gerald, Geissler, Klaus, Quehenberger, Franz, Kolch, Walter, Athineos, Dimitris, Blyth, Karen, Wölfler, Albert, Sill, Heinz, Zebisch, Armin
פורמט: Artigo
שפה:Inglês
יצא לאור: Ferrata Storti Foundation 2020
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012480/
https://ncbi.nlm.nih.gov/pubmed/31097632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.209650
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