MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2

Humoral immune responses initiate in the lymph node draining the site of viral infection (dLN). Some viruses subvert LN B cell activation; however, our knowledge of viral hindrance of B cell responses of important human pathogens is lacking. Here, we define mechanisms whereby chikungunya virus (CHIK...

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Udgivet i:PLoS Pathog
Main Authors: McCarthy, Mary K., Reynoso, Glennys V., Winkler, Emma S., Mack, Matthias, Diamond, Michael S., Hickman, Heather D., Morrison, Thomas E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012455/
https://ncbi.nlm.nih.gov/pubmed/31999809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008292
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