Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi

Sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors targeting the α-class enzyme from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were recently reported. Although many such derivatives showed low nanomolar activity in vitro, they were inefficient anti-T. cruzi age...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Autores principales: Vermelho, Alane Beatriz, da Silva Cardoso, Verônica, Ricci Junior, Eduardo, dos Santos, Elisabete Pereira, Supuran, Claudiu T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011998/
https://ncbi.nlm.nih.gov/pubmed/29192555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1405264
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