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HSV-1 DNA polymerase 3′-5′ exonuclease-deficient mutant D368A exhibits severely reduced viral DNA synthesis and polymerase expression
Herpesviruses, including herpes simplex virus-1, encode and express a DNA polymerase that is required for replication of their dsDNA genomes. The catalytic subunit of this enzyme contains a 3′-5′ exonuclease that is involved in proofreading during replication. Although certain mutations that severel...
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| Publicado no: | J Gen Virol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Microbiology Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7011708/ https://ncbi.nlm.nih.gov/pubmed/30176164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001138 |
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