Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion

[Image: see text] A robust nickel-catalyzed oxidative isocyanide insertion/C–H amination by reaction of readily available N-uracil-amidines with isocyanides affording polysubstituted pyrimidouracils has been reported. The reaction proceeds in moderate to quantitative yield, under mild conditions (i....

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Collet, Jurriën W., Morel, Bénédicte, Lin, Hung-Chien, Roose, Thomas R., Mampuys, Pieter, Orru, Romano V. A., Ruijter, Eelco, Maes, Bert U. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011176/
https://ncbi.nlm.nih.gov/pubmed/31942797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b04387
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