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In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability

[Image: see text] Protein macrocyclization represents a very efficient strategy to increase the stability of protein tertiary structures. Here, we describe a panel of novel C3-symmetric tris-electrophilic agents and their use for the cyclization of proteins. These electrophiles are reacted with a pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Org Chem
Prif Awduron: Neubacher, Saskia, Saya, Jordy M., Amore, Alessia, Grossmann, Tom N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2019
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011175/
https://ncbi.nlm.nih.gov/pubmed/31790232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02490
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