In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability

[Image: see text] Protein macrocyclization represents a very efficient strategy to increase the stability of protein tertiary structures. Here, we describe a panel of novel C3-symmetric tris-electrophilic agents and their use for the cyclization of proteins. These electrophiles are reacted with a pr...

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Bibliographic Details
Published in:J Org Chem
Main Authors: Neubacher, Saskia, Saya, Jordy M., Amore, Alessia, Grossmann, Tom N.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2019
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011175/
https://ncbi.nlm.nih.gov/pubmed/31790232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02490
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