Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers

Chronic administration of efavirenz is associated with decreased serum bilirubin levels, probably through induction of UGT1A1. We assessed the impact of efavirenz monotherapy and UGT1A1 phenotypes on total, conjugated, and unconjugated serum bilirubin levels in healthy volunteers. Healthy volunteers...

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Udgivet i:Drug Metab Dispos
Main Authors: Collins, Kimberly S., Metzger, Ingrid F., Gufford, Brandon T., Lu, Jessica B., Medeiros, Elizabeth B., Pratt, Victoria M., Skaar, Todd C., Desta, Zeruesenay
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011111/
https://ncbi.nlm.nih.gov/pubmed/31888882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.089052
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