Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers

Chronic administration of efavirenz is associated with decreased serum bilirubin levels, probably through induction of UGT1A1. We assessed the impact of efavirenz monotherapy and UGT1A1 phenotypes on total, conjugated, and unconjugated serum bilirubin levels in healthy volunteers. Healthy volunteers...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Drug Metab Dispos
Hlavní autoři: Collins, Kimberly S., Metzger, Ingrid F., Gufford, Brandon T., Lu, Jessica B., Medeiros, Elizabeth B., Pratt, Victoria M., Skaar, Todd C., Desta, Zeruesenay
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2020
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011111/
https://ncbi.nlm.nih.gov/pubmed/31888882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.089052
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky