A Multi-tissue Transcriptome Analysis of Human Metabolites Guides Interpretability of Associations Based on Multi-SNP Models for Gene Expression

There is particular interest in transcriptome-wide association studies (TWAS) gene-level tests based on multi-SNP predictive models of gene expression—for identifying causal genes at loci associated with complex traits. However, interpretation of TWAS associations may be complicated by divergent eff...

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Udgivet i:Am J Hum Genet
Main Authors: Ndungu, Anne, Payne, Anthony, Torres, Jason M., van de Bunt, Martijn, McCarthy, Mark I.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010967/
https://ncbi.nlm.nih.gov/pubmed/31978332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.01.003
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