Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice

SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations in axonal branching and cortical synaptic dynamics, accompanied by working memory deficits. We show that Setd1a binds bot...

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Udgivet i:Neuron
Main Authors: Mukai, Jun, Cannavò, Enrico, Crabtree, Gregg W., Sun, Ziyi, Diamantopoulou, Anastasia, Thakur, Pratibha, Chang, Chia-Yuan, Cai, Yifei, Lomvardas, Stavros, Takata, Atsushi, Xu, Bin, Gogos, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010348/
https://ncbi.nlm.nih.gov/pubmed/31606247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.09.014
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