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Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice
SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations in axonal branching and cortical synaptic dynamics, accompanied by working memory deficits. We show that Setd1a binds bot...
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| Publicado no: | Neuron |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7010348/ https://ncbi.nlm.nih.gov/pubmed/31606247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.09.014 |
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