Clarification of some aspects related to genotoxicity assessment

The European Commission requested EFSA to provide advice on the following: (1) the suitability of the unscheduled DNA synthesis (UDS) in vivo assay to follow‐up positive results in in vitro gene mutation tests; (2) the adequacy to demonstrate target tissue exposure in in vivo studies, particularly i...

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Bibliografiske detaljer
Udgivet i:EFSA J
Main Authors: Hardy, Anthony, Benford, Diane, Halldorsson, Thorhallur, Jeger, Michael, Knutsen, Helle Katrine, More, Simon, Naegeli, Hanspeter, Noteborn, Hubert, Ockleford, Colin, Ricci, Antonia, Rychen, Guido, Silano, Vittorio, Solecki, Roland, Turck, Dominique, Younes, Maged, Aquilina, Gabriele, Crebelli, Riccardo, Gürtler, Rainer, Hirsch‐Ernst, Karen Ildico, Mosesso, Pasquale, Nielsen, Elsa, van Benthem, Jan, Carfì, Maria, Georgiadis, Nikolaos, Maurici, Daniela, Parra Morte, Juan, Schlatter, Josef
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Scientific Opinion
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7009892/
https://ncbi.nlm.nih.gov/pubmed/32625393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2903/j.efsa.2017.5113
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