Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease caused by motor neuron loss, resulting in muscle wasting, paralysis and eventual death. A key pathological feature of ALS is cytoplasmically mislocalized and aggregated TDP-43 protein in >95% of cases, which is...

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Détails bibliographiques
Publié dans:Brain
Auteurs principaux: Smethurst, Phillip, Risse, Emmanuel, Tyzack, Giulia E, Mitchell, Jamie S, Taha, Doaa M, Chen, Yun-Ru, Newcombe, Jia, Collinge, John, Sidle, Katie, Patani, Rickie
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
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Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7009461/
https://ncbi.nlm.nih.gov/pubmed/32040555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz419
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