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Design and analysis of a clinical trial using previous trials as historical control

BACKGROUND/AIMS: For single arm trials, a treatment is evaluated by comparing an outcome estimate to historically reported outcome estimates. Such a historically controlled trial is often analyzed as if the estimates from previous trials were known without variation and there is no trial to trial va...

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Detalhes bibliográficos
Publicado no:Clin Trials
Main Authors: DA, Schoenfeld, DM, Finkelstein, E, Macklin, N, Zach, DL, Ennist, AA, Taylor, N, Atassi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008967/
https://ncbi.nlm.nih.gov/pubmed/31256630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774519858914
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