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Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist
Calcium-mediated signaling through inositol 1,4,5-triphosphate receptors (IP(3)Rs) is essential for the regulation of numerous physiological processes, including fertilization, muscle contraction, apoptosis, secretion, and synaptic plasticity. Deregulation of IP(3)Rs leads to pathological calcium si...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008357/ https://ncbi.nlm.nih.gov/pubmed/31915246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011570 |
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