Hesperetin-5,7,3ʹ-O-Trimethylether Dually Inhibits Phosphodiesterase 3/4 and Methacholine-Induced Airway Hyperresponsiveness in Sensitized and Challenged Mice

INTRODUCTION: Hesperetin-5,7,3ʹ-O-trimethylether (HTME), a synthetic liposoluble hesperetin, has been reported to be a dual phosphodiesterase (PDE)3/4 inhibitor. We investigated its inhibitory effects on methacholine (MCh)-induced airway hyperresponsiveness (AHR) and its potential for treating atypi...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Shih, Chung-Hung, Wang, Wen-Hung, Chen, Chi-Ming, Ko, Wun-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007784/
https://ncbi.nlm.nih.gov/pubmed/32099334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S227432
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