Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results from a National Biobank

RATIONALE: Genome-wide association studies have identified over 100 genetic loci for atrial fibrillation (AF); recent work described an association between loss-of-function (LOF) variants in TTN and early-onset AF. OBJECTIVE: We sought to determine the contribution of rare and common genetic variati...

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Publicat a:Circ Res
Autors principals: Choi, Seung Hoan, Jurgens, Sean J., Weng, Lu-Chen, Pirruccello, James P., Roselli, Carolina, Chaffin, Mark, Lee, Christina, Hall, Amelia W., Khera, Amit V., Lunetta, Kathryn L., Lubitz, Steven A., Ellinor, Patrick T.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007701/
https://ncbi.nlm.nih.gov/pubmed/31691645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315686
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