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A strategy for designing allosteric modulators of transcription factor dimerization
Transcription factors (TFs) are fundamental in the regulation of gene expression in the development and differentiation of cells. They may act as oncogenes and when overexpressed in tumors become plausible targets for the design of antitumor agents. Homodimerization or heterodimerization of TFs are...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7007557/ https://ncbi.nlm.nih.gov/pubmed/31953259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915531117 |
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