Arrhythmogenic late Ca(2+) sparks in failing heart cells and their control by action potential configuration

Sudden death in heart failure patients is a major clinical problem worldwide, but it is unclear how arrhythmogenic early afterdepolarizations (EADs) are triggered in failing heart cells. To examine EAD initiation, high-sensitivity intracellular Ca(2+) measurements were combined with action potential...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Fowler, Ewan D., Wang, Nan, Hezzell, Melanie, Chanoit, Guillaume, Hancox, Jules C., Cannell, Mark B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007549/
https://ncbi.nlm.nih.gov/pubmed/31969455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918649117
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