Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington’s Disease

There is currently no disease-modifying treatment for Huntington’s disease (HD), which is characterized by chorea motor impairment and cognitive decline. The zinc ionophore, PBT2, was previously shown to improve the phenotype of a HD mouse model and reported efficacy in certain cognitive tests in a...

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Bibliographische Detailangaben
Veröffentlicht in:Neurotherapeutics
Hauptverfasser: Ayton, Scott, Lei, Peng, Appukuttan, Ambili T., Renoir, Thibault, Foliaki, Simote, Chen, Feng, Adlard, Paul A., Hannan, Anthony J., Bush, Ashley I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007468/
https://ncbi.nlm.nih.gov/pubmed/31520307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00785-6
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