N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug

In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure models such as the maximal electroshock (MES) test, the subcutaneous pentylene...

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Detalhes bibliográficos
Publicado no:Neurotherapeutics
Main Authors: Kamiński, Krzysztof, Socała, Katarzyna, Zagaja, Mirosław, Andres-Mach, Marta, Abram, Michał, Jakubiec, Marcin, Pieróg, Mateusz, Nieoczym, Dorota, Rapacz, Anna, Gawel, Kinga, Esguerra, Camila V., Latacz, Gniewomir, Lubelska, Annamaria, Szulczyk, Bartłomiej, Szewczyk, Aleksandra, Łuszczki, Jarogniew Jacek, Wlaź, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007424/
https://ncbi.nlm.nih.gov/pubmed/31486023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00773-w
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