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Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice

The aim of the present study was to investigate the effect of sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, on threshold for clonic seizures in mice. In addition, the effects of sildenafil on the anticonvulsant activity of selected antiepileptic drugs (AEDs), i.e., clonazepam (CZP),...

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Bibliografiske detaljer
Main Authors: Nieoczym, Dorota, Socała, Katarzyna, Łuszczki, Jarogniew J., Czuczwar, Stanisław J., Wlaź, Piotr
Format: Artigo
Sprog:Inglês
Udgivet: Springer Vienna 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401299/
https://ncbi.nlm.nih.gov/pubmed/22315091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00702-012-0767-1
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