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HLA-DM Stabilizes the Empty MHCII Binding Groove: A Model Using Customized Natural Move Monte Carlo

[Image: see text] MHC class II molecules bind peptides derived from extracellular proteins that have been ingested by antigen-presenting cells and display them to the immune system. Peptide loading occurs within the antigen-presenting cell and is facilitated by HLA-DM. HLA-DM stabilizes the open con...

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Pubblicato in:J Chem Inf Model
Autori principali: Demharter, Samuel, Knapp, Bernhard, Deane, Charlotte, Minary, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007188/
https://ncbi.nlm.nih.gov/pubmed/31070900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.9b00104
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