HIV-1 Vaccine Sequences Impact V1V2 Antibody Responses: A Comparison of Two Poxvirus Prime gp120 Boost Vaccine Regimens

In the RV144 trial, vaccine-induced V1V2 IgG correlated with decreased HIV-1 risk. We investigated circulating antibody specificities in two phase 1 poxvirus prime-protein boost clinical trials conducted in South Africa: HVTN 097 (subtype B/E) and HVTN 100 (subtype C). With cross-subtype peptide mic...

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Publicado no:Sci Rep
Main Authors: Shen, Xiaoying, Laher, Fatima, Moodie, Zoe, McMillan, Arthur S., Spreng, Rachel L., Gilbert, Peter B., Huang, Ying, Yates, Nicole L., Grunenberg, Nicole, Juliana McElrath, M., Allen, Mary, Pensiero, Michael, Mehra, Vijay L., Der Meeren, Olivier Van, Barnett, Susan W., Phogat, Sanjay, Gray, Glenda E., Bekker, Linda-Gail, Corey, Lawrence, Tomaras, Georgia D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005751/
https://ncbi.nlm.nih.gov/pubmed/32034163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57491-z
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