Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair

Mutations in transforming growth factor-beta-induced (TGFBI) gene cause clinically distinct types of corneal dystrophies. To delineate the mechanisms driving these dystrophies, we focused on the R124C mutation in TGFBI that causes lattice corneal dystrophy type1 (LCD1) and generated novel transgenic...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Kitamoto, Kohdai, Taketani, Yukako, Fujii, Wataru, Inamochi, Aya, Toyono, Tetsuya, Miyai, Takashi, Yamagami, Satoru, Kuroda, Masahiko, Usui, Tomohiko, Ouchi, Yasuo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005300/
https://ncbi.nlm.nih.gov/pubmed/32029872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58876-w
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker