Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair

Mutations in transforming growth factor-beta-induced (TGFBI) gene cause clinically distinct types of corneal dystrophies. To delineate the mechanisms driving these dystrophies, we focused on the R124C mutation in TGFBI that causes lattice corneal dystrophy type1 (LCD1) and generated novel transgenic...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Kitamoto, Kohdai, Taketani, Yukako, Fujii, Wataru, Inamochi, Aya, Toyono, Tetsuya, Miyai, Takashi, Yamagami, Satoru, Kuroda, Masahiko, Usui, Tomohiko, Ouchi, Yasuo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005300/
https://ncbi.nlm.nih.gov/pubmed/32029872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58876-w
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