Generation of mouse model of TGFBI-R124C corneal dystrophy using CRISPR/Cas9-mediated homology-directed repair

Mutations in transforming growth factor-beta-induced (TGFBI) gene cause clinically distinct types of corneal dystrophies. To delineate the mechanisms driving these dystrophies, we focused on the R124C mutation in TGFBI that causes lattice corneal dystrophy type1 (LCD1) and generated novel transgenic...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kitamoto, Kohdai, Taketani, Yukako, Fujii, Wataru, Inamochi, Aya, Toyono, Tetsuya, Miyai, Takashi, Yamagami, Satoru, Kuroda, Masahiko, Usui, Tomohiko, Ouchi, Yasuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005300/
https://ncbi.nlm.nih.gov/pubmed/32029872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58876-w
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