Systematic dissection of biases in whole-exome and whole-genome sequencing reveals major determinants of coding sequence coverage

Advantages and diagnostic effectiveness of the two most widely used resequencing approaches, whole exome (WES) and whole genome (WGS) sequencing, are often debated. WES dominated large-scale resequencing projects because of lower cost and easier data storage and processing. Rapid development of 3(rd...

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Udgivet i:Sci Rep
Main Authors: Barbitoff, Yury A., Polev, Dmitrii E., Glotov, Andrey S., Serebryakova, Elena A., Shcherbakova, Irina V., Kiselev, Artem M., Kostareva, Anna A., Glotov, Oleg S., Predeus, Alexander V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005158/
https://ncbi.nlm.nih.gov/pubmed/32029882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59026-y
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