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Structure-Based Analysis of Cryptic Site Opening
Many proteins in their unbound structures have cryptic sites that are not appropriately sized for drug binding. We consider here 32 proteins from the recently published CryptoSite set with validated cryptic sites, and study whether the sites remain cryptic in all available X-ray structures of the pr...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Structure |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7004864/ https://ncbi.nlm.nih.gov/pubmed/31810712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.11.007 |
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