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Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown. We determine that low protein synthesis within hematopoietic stem cel...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Jose, Lorena Hidalgo San, Sunshine, Mary Jean, Dillingham, Christopher H., Chua, Bernadette A., Kruta, Miriama, Hong, Yuning, Hatters, Danny M., Signer, Robert A.J.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004491/
https://ncbi.nlm.nih.gov/pubmed/31914399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.003
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